This reference guide is intended to organize and suggest acceptable practices and procedures for dealing with safety in the area of chemistry instruction. It is intended as a resource for teachers, administrators and other school staff both in planning for science activities and in making daily decisions concerning safety. Sections include discussion of safety responsibility, safety training for students, chemicals, gases, heat sources, working with glass and plastics, accident prevention, and first aid. Several appendices deal with specialized considerations. (Author/RE)