This handbook was designed as a tool to assist school and agency staff in management and in-service training needed in implementing a comprehensive Career Information System (CIS). The background, goals, and organization of CIS are given briefly. An explanation of the System which is computer-based yet also employs a manual needle-sort system is presented. System components (such as the QUEST questionnaire, the QUEST List, occupational descriptions, occupational dumps, localized information, occupational books, VISIT, education and training information, and occupational interview cassettes) are discussed along with some background and validation information. Considerations mentioned in starting the System are selection and role of the coordinator, publicity, orientation to staff, and pre-service for the guidance staff which includes such practical information as location of the System and responsibility of counselors. Points to consider in implementing the System and in troubleshooting technical and personal problems are discussed. Abstracts of evaluative research are presented. Appendixes include copies of the evaluation questionnaires, the user agreement, and standards for use of the System. (SC)