A study was conducted to determine if eight distinct subcultures of college students reflect differences concerning psychological anomie (alienation) and existential frustration. In addition, the purpose of this study was to explore the interaction among eight college student subcultures and sex and race for psychological anomie and existential frustration. The eight subcultures of college students consisted of eight student types distinguishable in terms of their dominent value commitment. The subject sample consisted of 1306 students drawn from 89 colleges and universities. The eight subcultures were grouped as follows: (1) vocationalists, (2) professionalists, (3) collegiates, (4) ritualists, (5) academics, (6) intellectuals, (7) left activists, and (8) hippies. The results indicated that each of the subcultures studied exhibited some form of psychological anomie. It was suggested that belonging to a vocational or academic subculture might, in itself, reflect purposeful alienation from the institution. A number of implications, emphasizing the difficulty in dealing with alienation, are presented. (Author/BW)