Unit II of regional studies for grade five is arranged into three sub-units which comprise two case studies and look at the Midwest region as a whole. The objective of the case studies is to illustrate factors which bring about changing use of the land. Sub-unit one, a case study on Twin Cities, traces the cities' development from the days when the Indians inhabited the area up to today, comparing the development of one city which grew up around a water power site and another which developed at what was then the head of river navigation for steamers. Sub-unit two, case study on the Red River Valley, traces the region in four different periods from Indian-occupied territory to the present. The study shows changes in crops grown in terms of changing markets. Sub-unit three looks at the chief characteristics of the entire Midwest region and raises the question: Should the Upper Midwest be included in the same region as the rest of this area? The teacher's guide provides program descriptions, course objectives, teaching strategies, and an explanation of format in ED 062 226. Other related documents are a selected reading on the Red River Valley ED 062 227, ED 061 134, and SO 002 732 through SO 002 741. (Several pages may be illegible.) (Author/SJM)