Long-range biomedical manpower needs up to 1985 have been projected and the best estimate indicates that there will be an increase from 64,000 workers in 1965 to 150,000 in 1985. The related expenditure is expected to increase from 1.9 billion dollars to 15.7 billion dollars in the same period. Alternate predictions, based on other possible economic policies, lead to different results. The methods used, and the assumption made, for each projection are discussed. The period from 1947 to 1967 is used for a base, and a comparison of similar projections made in 1961 with the actual figures up to 1967 demonstrates the utility of the model. The projections imply that there will be (a) a need to fully utilize Ph.D.'s research skills; (b) a decrease in the proportion of M.D.'s trained as clinical investigators; (c) continued need for expansion of National Institute of Health training facilities; and (d) a need to continue accelerating expansion of facilities and equipment for health research. Appendices tabulate the projections, define biomedical research, and list localities where graduate education is expected to significantly expand. (AL)