Financial and manpower data on research, development and instruction in the sciences and engineering in universities and colleges and in university-administered federally funded Research and Development Centers are reported. Information was obtained from analyses of questionnaires sent to each university. Field visits and telephone followups were continued up to December 15, 1965, the cutoff date for the report. Each institution was asked for information on the scientific activities of all its branches and other units both on and off the main campus. Separate data were requested for 89 medical schools and 59 agricultural experiment stations. The data are reported in seven sections. Sections 1, 2, and 3 analyze expenditures for research, development, and instruction in the sciences and engineering. Sections 4 and 5 summarize employment data on scientific and engineering personnel. Section 6 discusses medical schools; section 7, agricultural experiment stations and schools of agriculture. (BC)