THIS CURRICULUM GUIDE DESCRIBES A TWELFTH-GRADE INTERDISCIPLINARY, INTRODUCTORY NUCLEAR SCIENCE COURSE. IT IS BELIEVED TO FILL THE NEED FOR AN ADVANCED COURSE THAT IS TIMELY, CHALLENGING, AND APPROPRIATE AS A SEQUENTIAL ADDITION TO THE BIOLOGY-CHEMISTRY-PHYSICS SEQUENCE. PRELIMINARY INFORMATION COVERS SUCH MATTERS AS (1) RADIOISOTOPE WORK AREAS, (2) NUCLEAR SCIENCE LABORATORY, (3) PURCHASING EQUIPMENT, (4) CONSTRUCTION AND MODIFICATION OF EQUIPMENT, (5) LICENSING AND LEGAL REQUIREMENTS, (6) STANDARDS FOR PROTECTION AGAINST RADIATION, AND (7) THE SAFE USE OF RADIOISOTOPES. THE SECOND PART OF THE DOCUMENT PRESENTS A SUGGESTED SYLLABUS FOR A ONE-SEMESTER COURSE IN NUCLEAR SCIENCE, AND INCLUDES (1) CONTENT OUTLINE, (2) LEARNING EXPERIENCES AND LABORATORY EXPERIMENTS, (3) TEXT REFERENCES, AND (4) AUDIOVISUAL AIDS (ANNOTATED FILM LISTS). SUPPLEMENTARY SECTIONS INCLUDE (1) NUCLEAR SCIENCE REFERENCE MATERIALS, (2) ATOMIC ENERGY COMMISSION (AEC) PUBLICATIONS, (3) FILMSTRIPS PREPARED BY THE RADIATION SCIENCE SEMINAR STAFF, (4) AEC FILM SERIES, (5) SIMPLE EXPERIMENTS FOR HIGH SCHOOL STUDENTS USING THE CIVIL DEFENSE V-700 GEIGER COUNTER, (6) AUTORADIOGRAPHY PROCESSING FORMULAS, (7) NUCLEAR EDUCATION EQUIPMENT, AND (8) NUCLEAR EQUIPMENT SUPPLIES. (DH)