THIS SET OF CONSIDERATIONS HAS BEEN PREPARED TO PROVIDE PERSONS WORKING ON THE DESIGN OF NEW OR REMODELED LABORATORY FACILITIES WITH A SUITABLE REFERENCE GUIDE TO DESIGN SAFETY. THERE IS NO DISTINCTION BETWEEN TYPES OF LABORATORY AND THE EMPHASIS IS ON GIVING GUIDES AND ALTERNATIVES RATHER THAN DETAILED SPECIFICATIONS. AREAS COVERED INCLUDE--(1) AUTOMATIC SYSTEMS FOR FIRE AND EXPLOSION PROTECTION, (2) EMERGENCY ALARM SYSTEMS, (3) SPECIAL FACILITIES FOR CHEMICAL STORAGE, HANDLING, AND DISPOSAL, (4) SAFETY EQUIPMENT, (5) FACILITIES FOR INFECTIOUS AGENTS AND ANIMALS, (6) LABORATORY VENTILATION, (7) ILLUMINATION, (8) RADIO ISOTOPES, (9) EGRESS FACILITIES, (10) FIRE RESISTANCE, (11) WATER SUPPLY AND PIPING, AND (12) MISCELLANEOUS DESIGN FEATURES. SPECIAL EMPHASIS IS GIVEN TO LABORATORY VENTILATION, AND A BIBLIOGRAPHY IS PROVIDED ON INFECTIOUS AGENTS AND ANIMALS. (MM)