Although links between knowledge and reading comprehension have been widely documented for decades, recent translational science publications (e.g., teacher journals, books, and podcasts) have increasingly referred to studies using baseball (a sport popular in the USA) as a proxy for knowledge to explain those links, especially within science of reading conversations. We conducted a systematic review of studies using baseball as a proxy for knowledge necessary for reading comprehension. After a comprehensive literature search, we found 19 "baseball studies" dating from 1978 to 2018, and we note that 13 of the studies used the same two measures of baseball knowledge. When analyzing the measures of baseball knowledge, we find that their measures of knowledge focused heavily on vocabulary and baseball trivia, and we found that the most common baseball comprehension text was deceptively complex. Finally, we analyzed recent research citations of baseball studies and found that even the oldest baseball studies are commonly cited in high-impact journals even in the last 5 years. Ultimately, we interrogate the role of baseball knowledge studies in the body of research on knowledge and comprehension. We also call for reliance on non-baseball studies to create a knowledge-comprehension translational science likely to positively impact systematic curricular improvement, move the science of reading conversation forward, and improve all students' reading comprehension at scale.