The aim of this article is to review the importance of the question of life's meaning, mainly for intellectually gifted, as well as suggesting possibilities for educational and therapeutic approaches with an integration between Dabrowski's proposals and Frankl's and Yalom's existential psychotherapies for enhancing meaning. In particular, we suggest that "a successful transition between childhood and adult giftedness depends upon the gifted individual's finding meaning in their life and a sense of purpose through which to try to achieve it." The article is based on an integration of theory-based propositions, a review of existing research, and clinical observations. We conclude that it is important to integrate ideas about existential problems into education and psychotherapy for the gifted, increasing gifted individuals' sense of meaning through development of human values, a eudaimonic life orientation, full expression of potential, generativity, harmony, self-compassion, and spirituality.