This study examined the early implementation stages of the Modeling Method of Instruction (MMI) in the science classroom to find the most valuable strategies for effective implementation. In this qualitative study, eleven teachers were interviewed to uncover effective implementation strategies. Interview data were analyzed using the constant comparative method. The focus of this study was to discover challenges faced in the exploration and installation phases of MMI implementation and the best strategies used by seasoned modelers. MMI is a research-based inquiry framework encompassing the Next Generation Science Standards (NGSS). Addressing the multiple components for effective delivery is critical in exploring and installing new scientific instructional programs like MMI. In addition, purposeful planning ensures fidelity of implementation. Further, support throughout installation is essential to effective inquiry teaching and learning. The study determined that training is required for maximum success of the Modeling Method of Instruction. Additionally, teacher leadership qualities and flexibility are critical factors for successful implementation, especially throughout the initial phases. Further, being patient and using data to increase MMI's effectiveness benefits the modeler's trust in the process. Finally, the study concluded that there is an overwhelming need for mentoring to improve the support necessary for implementing MMI effectively. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]