Efavirenz (EFV) is a well-known, effective anti-retroviral drug long used in first-line treatment for children and adults with HIV and HIV/AIDS. Due to its narrow window of effective concentrations, between 1 and 4 µg/mL, and neurological side effects at supratherapeutic levels, several investigations into the pharmacokinetics of the drug and its…

Developing treatment strategies to enhance memory is an important goal of neuroscience research. Activation of multiple biochemical signaling cascades, such as the protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, is necessary to induce long-term synaptic facilitation (LTF), a correlate of long-term memory (LTM).…

Background: Model-based meta-analysis (MBMA) is increasingly used to inform drug-development decisions by synthesising results from multiple studies to estimate treatment, dose-response, and time-course characteristics. Network meta-analysis (NMA) is used in Health Technology Appraisals for simultaneously comparing effects of multiple treatments,…

Few studies have examined the impact of alcohol on metacognition for witnessed events. We used a 2 × 2 balanced placebo design, where mock witnesses expected and drank alcohol, did not expect but drank alcohol, did not expect nor drank alcohol, or expected but did not drink alcohol. Participants watched a mock crime in a bar-lab, followed by free…

In both 2016 and 2019, the NCLEX-RN (National Council Licensure Examination -- RN computerized exam) test plan outlined 15% of content as "pharmacological and parenteral therapies". The test plan also includes physiological sciences. The topics of pharmacology encompass the review of drug action in living organisms, such as humans. As…

The blended learning material of gastrointestinal (GI) pharmacotherapy was noted by students as needed improvement. As pharmacology is the core component of pharmacotherapy, it was hypothesised that improved students engagement with online learning of GI pharmacology will engage and motivate students in the learning of GI pharmacotherapy.…

An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for…

Instructional Systems Design is the practice of creating of instructional experiences that make the acquisition of knowledge and skill more efficient, effective, and appealing [18]. Specifically in designing courses, an hour of training material can require between 30 to 500 hours of effort in sourcing and organizing reference data for use in just…

An interactive MATLAB simulation app and design project are described for introducing chemical engineering concepts to engineering freshmen. A MATLAB simulation for pharmaceutical drug dosing is packaged with a graphical user interface in an app that is student friendly. Minimal engineering or coding knowledge is necessary to operate and…

This article offers a longitudinal computational-rhetorical analysis of biomedical writing on opioids. Using a corpus of 1,467 articles and essays published in the "New England Journal of Medicine" and the "Journal of the American Medical Association" between 1959 and May 2019, this study evaluates diachronic shifts in (a) the…

This paper reports the development of a digital escape room for high school students using Genially, a web-based media platform. The escape room was used to aid understanding of basic concepts in chemistry and mostly enhance students' classes participation during the COVID-19 pandemic. The activity entitled "The thalidomide mystery"…

Collaboration between academia and actors outside academia (AOAs) has been proclaimed as a way for society to confront challenges in different fields. This 'participatory imperative' is anchored in EU research policy. The paper explores the participatory imperative in contemporary Swedish aging research. Three kinds of motives for participatory…

Indirect treatment comparisons are useful to estimate relative treatment effects when head-to-head studies are not conducted. Statisticians at the National Centre for Pharmacoeconomics Ireland (NCPE) and Scottish Medicines Consortium (SMC) assess the clinical and cost-effectiveness of new medicines as part of multidisciplinary teams. We describe…

Here, students determine aspirin (acetylsalicylic acid) mass in pharmaceutical tablets using a colorimetric method. Aspirin, salicylate, and salicylic acid do not absorb visible light. Thus, in alkaline medium, acetylsalicylic acid was hydrolyzed to salicylate; then, it was reacted with an acidic Fe(III) solution, and a violet complex was formed.…

In the current day and age, innovation is the fodder that keeps companies and institutions running, and universities play an important role. During the crisis and in the post-crisis period, financial support for research and development have undergone significant changes especially at universities. The aim of this research is to conduct a patent…