Marion D. Francis and Rosemary L. Centner tell the story of a special group of compounds, developments at their home company, Procter and Gamble, and contributions by researchers in Europe and the U.S., in "The Development of Diphosphonates as Significant Health Care Products."

Using a patented drug during clinical trials is not infringement [35 U.S.C. 271(e)(1)]. Merck v Integra enlarged this "safe harbour" to accommodate preclinical use of drugs and patented "research tools" if "reasonably related" to FDA approval. The decision allowed lower courts, should they wish, to find any use of a research tool, except for…

Temple College (TC) is a comprehensive community college located in Temple, Texas. Temple also is home to Scott & White Hospital, Central Texas Veterans Health Care System, King's Daughters Hospital, and Texas A&M University College of Medicine's clinical campus. In the summer of 2001, TC's health-sciences programs were scattered across…

It seems hard to believe that Dolly the cloned sheep was born 10 years ago, kindling furious arguments over the prospects and ethics of cloning a human. Today, the controversy over cloning is entwined, often confused, with concerns over the use of human embryonic stem cells. Most people are unclear what cloning is, and they know even less when it…

Greatly modifying the present medical curriculum for the future physician-scientist is not recommended. The value of his having a PhD is questioned and the importance of his working in a hospital-based clinical department is stressed. The author contends that emphasizing the interrelationship between basic and applied research will increase public…

The authors present an overview of recent developments and ultimate goals in quality of care assessment, with special reference to the nurse practitioner. A proposed evaluation model is included. (Author)

A longitudinal study of the expectations of nurse practitioner (Primex) students at UCLA and their job evaluations (before, during, and after training and preceptorship) reported more interest, variety, and creativity without corresponding salary increases in their new roles. However, the role of nurse practitioner was more stressful and less…

Sequential urinalysis of four premature infants with marked physiologic anemia demonstrated no erythropoietin (substances which may stimulate red blood cell formulation). (CL)

Levels of serum IgE (an immunoglobulin carrying reaginic antibody activity) were investigated in 16 Down's syndrome adolescents (12-to 18-years old) and in an equal number of retardates matched for age and sex residing in the same institution. (CL)

Banding techniques were used in follow-up chromosome studies on two adult institutionalized retardates who had been previously described as having a low ridge count due to a high number of arches on the fingertips associated with undefined chromosomal abnormalities. (CL)

This report summarizes advances in the understanding of Alzheimer's disease, the major cause of mental disability among older Americans. The demography of the disease is discussed, noting that approximately 2.5 million American adults are afflicted with the disease and that the large increase in the number of Alzheimer's disease patients is due to…

The objective of research in contraceptive evaluation is to improve the ability of individuals to choose contraceptive methods best suited to their needs and circumstances and to provide information that will lead to the development of safer and more effective methods. There are usually three considerations in judging the importance of a method of…