In the present study, voice onset time (VOT) measurements were compared between a group of individuals with moderate Alzheimer's disease (AD) and a group of healthy age- and gender-matched peers. Participants read a list of consonant-vowel-consonant (CVC) words, which included the six stop consonants. The VOT measurements were made from…

Early differential diagnosis of dementia is becoming increasingly important as new pharmacologic therapies are developed, as these treatments are not equally effective for all types of dementia. Early detection and differential diagnosis also facilitates informed family decision making and timely access to appropriate services. Information about…

This study sought to develop an instrument for the assessment of grief in caregivers of persons with Alzheimer's disease. Study resulted in a 50-item scale containing three factors. Results suggest that caregiver grief is neither a unitary nor static construct and that a scale such as this may be appropriate for use in supportive, clinical, and…

A comparison of 12 persons with Parkinson's disease (PD), 12 with Alzheimer's disease (AD), and 12 in a control group on a memory scanning task found some slow scanning speed in PD patients. Despite normal scanning speed, most AD patients required highly structured instructions to complete the task, and many remained unable to do so. (SK)

Analysis of a conversation with an Alzheimer's disease sufferer with word-finding problems revealed that social context, speaker characteristics, and awareness of the other speaker's perspective governed such conversational aspects of turn taking and turn giving, which allowed full development of both speakers' personas. (23 references) (CB)

Purpose: This study was designed to examine the factors associated with the preferences of Alzheimer's disease patients to participate in a decision to use an Alzheimer's disease-slowing medication and how involved their caregivers would let them be in this decision. Design and Methods: Interviews were conducted with 48 patients in the…

The cognitive reserve hypothesis proposes that a high educational level could delay the clinical expression of Alzheimer's disease (AD) although neuropathologic changes develop in the brain. Therefore, some studies have reported that when the clinical signs of the disease emerge, high-educated patients may decline more rapidly than low-educated…

Reaction time (RT) tasks take various forms, and can assess psychomotor speed, (i.e., simple reaction time task), and focused attention (i.e., choice reaction time (CRT) task). If cues are provided before stimulus presentation (i.e., cued choice reaction time (CCRT) task), then a cueing effect can also be assessed. A limited number of studies have…

The hypothesis that Alzheimer's disease (AD) degrades semantic representations predicts that AD qualitatively alters spontaneous thoughts. In two experiments contrasting free associations to words with strong (e.g., "bride-groom") versus weak (e.g., "body-leg") associates participants with AD produced less common responses (e.g., "bride-pretty")…

A newly developed quantitative near-infrared spectroscopy (NIRS) system was used to measure changes in cortical hemoglobin oxygenation during the Verbal Fluency Task in 32 healthy controls, 15 subjects with mild cognitive impairment (MCI), and 15 patients with Alzheimer's disease (AD). The amplitude of changes in the waveform, which was…

We report data from a group of patients with mild Alzheimer's disease on a range of tasks requiring either stored semantic knowledge about objects (e.g., naming object use) or the execution of action to objects (e.g., miming and using objects). We found that the patients were impaired at miming in response to objects, even when they could describe…

This document contains two brief bibliographies of peer-reviewed literature, with abstracts, on dementia and Alzheimer's disease in the elderly, one written for the educator and the other for the consumer. They are two of 12 bibliographies on aging prepared by the National Agricultural Library for its "Pathfinders" series of publications. Topics…

This study focused on one question: Do caregiver responses--emotion-focused coping, problem-focused coping, appraisal of burden, and appraisal of satisfaction--mediate or moderate the effects of caregiving stress on psychological well-being? Findings indicate that development of interventions that focus on how caregivers appraise their situation,…

Argues that social gerontologists have adopted biomedical model of senile dementia, neglecting social factors involved in definition and interpretation of brain disease and in experience of dementing illness. Critiques biomedical model, including definition of pathology, attribution of behavioral changes to disease stages, and legitimation of…

Studied 127 informal caregivers of Alzheimer's disease patients to determine correlates of 5 components of burden as measured by Cost of Care Index. Significant relationships between predictor variables and burden components suggest that global scores and measures of burden do not identify specific problem areas relative to various components of…