There is a paucity of research on chronic illness among post-secondary students despite increasing numbers of individuals pursuing a college education with chronic illness and medical conditions (Herts et al., 2014; Johnston et al., 2021; Pinquart, 2024). Migraine, an often painful neurological condition (Suzuki et al., 2022), is associated with psychological distress, stress (Moon et al., 2017; Vgontzas et al., 2021), and functional disability among post-secondary students (Buse et al., 2023; Panigrahi et al., 2020). In addition, students from historically marginalized groups report stress related to experiencing microaggressions, which not only compounds their overall stress levels but also is associated with poorer physical health, mental health and academic performance (Mouzon et al., 2017; Overstreet et al., 2022; Robinson-Perez et al., 2019; Williams, 2021). Post-secondary institutions, including college counseling centers face challenges in addressing chronic illness among students (Ball & Tuckwiller, 2024; Lemly et al., 2014) and often do not sufficiently address the unique stressors related to microaggressions (Mills, 2020; Sue et al., 2007). Moreover, there is a gap in the literature exploring social determinants of health such as microaggressions and how they impact the expression, experience, and trajectory of medical conditions. This dissertation is a secondary analysis of The Fall 2022 American College Health Association's National College Health Assessment (ACHA-NCHA III), a survey (N = 23,866) of health characteristics and stressors among post-secondary students in the United States. The primary goals of this dissertation were to describe and summarize the experience of microaggressions and migraine among undergraduate college students ages 18-29 (N = 22,371), explore the potential association between microaggressions and migraine, and their potential relationships with psychological distress, perceived stress, and academic performance among a sample of undergraduate students. The results demonstrated that the experience of microaggressions was significantly associated with reports of migraine, and students reporting microaggressions or migraine had significantly higher psychological distress relative to those without migraine. Reports of microaggressions significantly predicted non-specific psychological distress scores (i.e., K6) among students reporting migraine. Reports of microaggressions and migraine predicted a small yet significant proportion of variance in level of stress (e.g., higher stress), and students reporting microaggressions were significantly more likely to report higher academic interference from their migraines. The implications of this secondary analysis include a better understanding of microaggressions and migraine for post-secondary students in a sociocultural context. Recommendations and potential interventions for post-secondary institutions and counselors working with college students who experience microaggressions and/or have migraines are reviewed. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]