Objective: To provide an initial description of the effectiveness and pharmacokinetics (PK) of quetiapine in aggressive children with conduct disorder (CD). Method: This 8-week, open-label outpatient trial, enrolled patients ages 6 to 12 years with CD. Outcome measures included the Rating of Aggression Against People and/or Property Scale…

Purpose: The aim of this study is to investigate teachers' attitudes towards medicines and to determine what they are willing to teach children about medicines. This study is part of a larger project where medicine education materials accessible on the internet (www.uku.filaakekasvatus, in Finnish with English introduction) were designed,…

This article deals with a 16-year-old boy who is referred by his parents to address his academic decline and mood symptoms. He was diagnosed with attention-deficit/hyperactivity disorder (ADHD) 7 years ago, but his parents had opted not to have it treated. The patient has prominent inattention and distractibility, with complaints of internal…

The availability of an increased variety of therapeutic approaches provides the opportunity to improve hypertension control while minimizing adverse effects that may influence cardiovascular complications and adherence to therapy. This report serves two purposes: (1) to guide practicing physicians and other health professionals in their care of…

This is a review of the pharmacological treatment of mental illnesses. Included topics are: schizophrenia, depression, mania, antipsychotic drugs, antidepressants, lithium, and ethics. (BB)

A national survey of physiology, pharmacology, and surgery departments found that while laboratory exercises using animals are common, they are not universal, and that the widely available alternatives assume diverse forms, including films, computer models, lectures, readings, and clinical clerkships. (MSE)

Discusses advantages and disadvantages of using computer simulations (including those involving application of mathematical models) in teaching physiology and pharmacology, indicating that the major benefit is in performing experiments that cannot be performed in the laboratory. Also considers a simulation on the interaction of drugs with…

Describes compilation of data concerning pharmaceutical journal coverage in online databases which aid information providers in collection development and database selection. Methodology, results (a core collection, overlap, timeliness, geographic scope), and implications are discussed. Eight references and a list of 337 journals indexed online in…

Discusses programs designed to ease shortage of qualified toxicologists including one leading to a bachelor's degree in toxicology at the Philadelphia College of Pharmacy and Science. Also considered are emerging attitudes toward toxicology and educational issues extending beyond the education of students (such as educating the public,…

Meta-analysis of 33 studies examined effect size for nonstimulant medications on symptoms of overt aggression-related behaviors in children and adolescents with serious emotional and behavioral disturbances. Thirty-seven independent effects were found for neuroleptic, atypical antipsychotic, mood stabilizer, antidepressant, and adrenergic agents…

A survey was sent to eighty-five American Association of Colleges of Pharmacy-member schools and affiliates to learn how many lectures are accorded to core sequences in pharmacology. The data were intended to provide a frame of reference for the University of Toledo College of Pharmacy. (Author/MLW)

Computer simulation of drug formulation problems involves a database of pharmacological properties, chemical stability, and compatibility data on 20 active ingredients, physiological factors and requirements for parenteral solutions, and additives. The user gathers data from the database, formulates a stable and effective solution, and the drug is…

The efficacy of medications used to treat children with attention deficit disorders is reviewed, along with the importance of monitoring the medications' side effects. Medications reviewed include psychostimulants, tricyclic antidepressants, clonidine, and thyroid hormone. Factors to consider before recommendation of medication are listed.…

The molecular properties of Human Immunodeficiency Virus type 1 (HIV-1) reverse transcriptase are summarized and several strategies developed to inhibit its activity are described. (MSE)

Anticipated shifts in the demographics of the Acquired Immune Deficiency Syndrome (AIDS) epidemic are examined, current state-of-the-art AIDS patient management is summarized, and some unique facets of drug therapy in the AIDS patient are discussed, including adverse reactions, complex drug interactions, use of investigational drugs, and…