Oxidation reactions are critical components of the synthetic toolbox taught to undergraduate students during introductory organic chemistry courses. However, the oxidation reactions discussed in the undergraduate curriculum are often outdated as many organic chemistry textbooks emphasize chromium-based oxidants that are no longer in regular use by…

Organic chemistry students often struggle with reaction mechanisms, particularly in how they are proposed and justified. In this activity targeting second year organic undergraduates, students used infrared spectroscopy (IR) to track the reaction progress of two distinct aldol reactions and used polarimetry to analyze the stereoselectivity of…

A community-engaged learning experiment was developed for an introductory analytical chemistry course at the University of Toronto Scarborough in collaboration with Campus Farm. The experiment introduced students to the application of analytical techniques to studying environmental samples. More specifically, students investigated the potential of…

A Maker-oriented experimental course in general chemistry has been created by using digital tools, such as a computer, a pressure sensor, and data processing software, in combination with a new multiple expansion method and laboratory equipment to determine the vapor pressure precisely. In this Maker chemistry experiment, the pressure sensor…

The preparation of ethyl acetoacetate is a distinctive, century-old classic organic chemistry laboratory project. Ethyl acetate and sodium metal (sodium ethoxide) are reacted by Claisen ester condensation to produce the sodium salt of ethyl acetoacetate and then obtain the refined product by acidification as well as washing, drying, and…

The dissolution of cobalt­(II) chloride in an appropriate binary alcohol solvent yields an equilibrium mixture, consisting of the differently colored octahedral (pink in color) and tetrahedral (blue in color) cobalt­(II) coordination complexes, which can exhibit a brilliant and reversible pink-to-blue color transition over a ~10 °C window - i.e.,…

For educational institutions in science, technology, engineering and mathematics (STEM) areas, the provision of practical learning scenarios is, traditionally, a major concern. In the 21st century, the explosion of information and communication technology (ICTs), as well as the universalization of low-cost hardware, has allowed the proliferation…

A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

Microfluidic-based ultramicroscale chemistry experiments involve the manipulation and consumption of reagents on a microliter or submicroliter scale in a microfluidic device. This article presents the pedagogical functions of microfluidic systems, including green chemistry education, stimulation of students' interest in learning about chemistry,…

Organizing undergraduates in chemistry, energy engineering, and chemical engineering specialties to participate in an energy transformation experiment can encourage them to think about the impact of human activities on nature and stimulate them to learn more about the topic. This laboratory experiment demonstrates a general approach to the…

Lateral flow assays play a key role in mass testing for COVID-19, for example, in schools. The red color of the detection lines is caused by gold nanoparticles that are conjugated to antibodies. Hence, these tests present a very topical learning opportunity in the emerging field of nanoscience. To highlight the role of gold nanoparticles, a…

A new undergraduate organic laboratory experiment has been developed and implemented for the Ugi three-component synthesis of the topical anesthetic lidocaine with excellent atom economy. Paraformaldehyde, diethylamine, and 2,6-dimethylphenyl isocyanide were combined and conveniently stirred at room temperature for a week in methanol with acetic…

Mercury beating heart (MBH) is a well-known demonstration of redox processes. However, the development and application of the MBH system are significantly restricted due to its safety issues. Here, a direct current electric field-enabled gallium-based liquid metal heartbeat in a salt solution or alkaline solution is introduced as a demonstration…

Undergraduate organic chemistry laboratory courses act as a baseline for introductory scientific experimentation. These courses provide students with the knowledge and skills for their future careers. The traditional lab is conducted by providing a structured protocol of the experiment for the students to follow and reproduce the assigned task…

A new undergraduate organic laboratory experiment has been developed for amide bond formation between biorenewable 2-furoic acid and either of two substituted piperazines to prepare medicinally relevant amide products using a procedure with industrial significance. The reactions proceeded smoothly under ambient conditions using the combination of…