The application of physico-chemical principles has been routinely used to explain various physiological concepts. The Nernst equation is one example of this, used to predict the potential difference created by the transmembrane ion gradient resulting from uneven ion distribution within cellular compartments and the interstitial space. This…

Background: Down Syndrome is the most common genetic disorder associated with intellectual and developmental disabilities. Research to improve health care outcomes in Down Syndrome lags significantly behind other disease categories. Among these reasons are funding, recruitment and availability of research studies being conducted. Methods: We…

Single-case experimental designs (SCEDs) are frequently used to evaluate whether a functional relation exists between interventions and student outcomes. A critical factor in decision making is the evaluation of graphical data, typically displayed in time-series graphs. Distortion in the graphical display of data can lead to invalid decisions on…

Common method variance refers to the amount of uncontrolled systematic error leading to biased estimates of scale reliability and validity and to spurious covariance shared among variables due to common method and/or common source employed in survey-based researches. As the extended use of self-report questionnaires is inevitable, numerous studies…

To initiate clinical research studies successfully and efficiently, it is critical to develop a strong, feasible, and well-written study protocol early in the start-up phase. The University of Minnesota's Clinical Research Support Center designed and implemented a structured Feasibility Review process in 2018 that addresses common start-up…

This Concise Review is an appraisal of contemporary research on teaching single-case experimental design (SCED) graphical creation published between 2017-2021. Recent work on SCED graphical creation is summarized and areas for future research are highlighted.

A latent variable modeling-based procedure is discussed that permits to readily point and interval estimate the design effect index in multilevel settings using widely circulated software. The method provides useful information about the relationship of important parameter standard errors when accounting for clustering effects relative to…

Understanding complex (social) phenomena benefits from combining different tools, perspectives, expertise, and experiences. Research designs that combine approaches are gaining in popularity. Carrying out research in interdisciplinary teams, however, is a challenging, high-investment activity. Unawareness of and reflecting on conflicting ways of…

Currently the design standards for single case experimental designs (SCEDs) are based on validity considerations as prescribed by the What Works Clearinghouse. However, there is a need for design considerations such as power based on statistical analyses. We compute and derive power using computations for (AB)[superscript k] designs with multiple…

Applied researchers faced with limited resources can utilize planned missing designs by incorporating missing data into their research design to collect more and higher quality data compared to a conventional experimental design. Two-method measurement planned missing designs (TMM-PMD) are a type of planned missing design whereby researchers…

Once research questions are posed, researchers must answer many a priori questions regarding research design before analysis can be performed and any conclusions can be made, including sample selection criteria, data collection method, model specification, analysis and estimation technique. The choices made by researchers along this forking path…

Over the past decade, transdisciplinary research has been faced with increasing demands by research policy and funding bodies to make its contribution to dealing with complex societal problems more transparent. In the literature, there is a range of methodological attempts to trace and describe the effects of transdisciplinary research, but these…

Considerably more research needs to be done to understand how successful technological innovations and change processes are sustained and scaled to new learning contexts. Without a better understanding of successful technological innovation, the wider field and education community are unable to benefit and build capacity. A model is presented that…

The main objective of this methodological article is to discuss the contribution of response times as a tool in education research. The use of response times in research is largely a legacy of the work carried out in cognitive psychology, which has made it possible to describe the cognitive processes involved in information processing. In…

Many teacher education researchers have expressed concerns about the lack of rigorous impact evaluations of teacher preparation practices. I summarize these various concerns as they relate to issues of internal validity, measurement, and external validity. I then assess the prevalence of these issues by reviewing 166 impact evaluations of teacher…