Early alcohol use places youth at risk for adverse health, academic, and legal consequences. We examined the content of the total array of self-cognitions in urban youth to determine whether specific self-concept profiles were associated with early drinking, drinking-related self-cognitions, and conduct problems. We conducted a secondary analysis of data from a cross-sectional study with 9- to 12-year-old predominantly Black and Hispanic youth (N = 79) who attended urban school and summer youth programs. Measures included an open-ended self-description task and questionnaires to measure presence/absence of a drinking-related self-cognition, alcohol use, and conduct problems. We content analyzed 677 self-descriptors; cluster analysis revealed six unique self-concept profile groups. In a cluster group distinguished by negative self-content, 37% drank alcohol and 42% had a drinking-related self-cognition. Youth in this group also had conduct problems. School nurses are in prime positions to identify and intervene with youth who have at-risk self-concept profiles.