In the United States, most mothers work during pregnancy. Yet, until the passage of the Pregnant Workers Fairness Act in 2022, pregnant employees did not have a right to reasonable accommodations to work under safe conditions. This law is expected to increase employment among pregnant women, making it critical to understand the effects of work during pregnancy on health and the potential benefits of the law. Because the prenatal period has long-lasting consequences for health, employment during pregnancy can affect children's health and development in childhood and beyond. In this article, we review theory and empirical evidence on the effects of work during pregnancy on maternal and infant health. We propose a conceptual framework that outlines the pathways through which work during pregnancy affects health, discuss policies that are expected to affect work during pregnancy and health and conclude with priorities for future research.