International comparative measures show that South Africa has extremely low standards in reading. A variety of programmes aimed at boosting reading have been developed, however, the effectiveness of these programmes is unclear. Prior reviews of effective reading instruction practices have focused almost exclusively on learners whose first language and language of instruction is English. This paper reviews evidence from 17 intervention studies which focused on the teaching of reading comprehension in the distinctive multilingual context of South Africa. Although in line with prior reviews, we found some evidence that reading strategy instruction including vocabulary development are features of successful interventions alongside effective teacher education and resourcing of reading. These findings remained inconclusive due to variability in the quality of research, considerable methodological variations of the studies and the limited number of studies. Research in this field requires a more rigorous scientific approach to improve the evidence base.