Developing social competence for preschoolers is an important area for early intervention, especially for young children with emotional and behavioral issues. This single case meta-analysis focused on examining the literature base for social skills interventions for preschoolers. A systematic search of the literature yielded 33 single-case studies on social skills interventions for preschoolers. Results from the aggregated single case studies using a baseline corrected Tau-U indicated a moderate to large effect (Baseline Corrected Tau = 0.66). Moderator analysis results showed gender and intervention format were statistically significant moderators for the intervention effect. Limitations and directions for future research were discussed within the context of social-behavioral research and early intervention in preschool settings.