Physical activity breaks in the classroom are an efficient way of promoting healthy behaviors in students, enhancing the development of their cognitive and academic abilities. The effects of active breaks, which are exclusive to the academic environment, are almost entirely positive, only a few papers did not show significant improvements, but they did not show any negative impact on academic performance either. This research was carried out to identify the properties and consequences of active breaks and physical activity during classes in school age. We have examined multiple databases, and we have selected 41 papers accounting for a time span of 15 years. Psychology, medicine, and education databases were the most browsed. Most papers revealed positive outcomes for improving skills related to mathematics, language, reading, comprehension, as well as cognitive and executive functions. Overall, the results of this review corroborate the theory that physical education in schools is positively associated with academic performance in children. Education researchers keep investigating in order to fully assess the positive impact on academic performance, behavior during classes, and cognitive functions.