Phasing out ineffective programs may free up resources for more effective alternatives and improve student outcomes. This review of the literature on the de-implementation process in schools includes a practical guide that can be used to ensure students receive the most effective services available. This framework can be applied to illustrate how school psychologists might lead de-implementation efforts across four key stages: (1) identifying and prioritizing programs appropriate for de-implementation; (2) assessing factors related to de-implementation; (3) developing strategies to support de-implementation; and (4) evaluating de-implementation outcomes.