Background: Perceived social support (PSS) is associated with positive outcomes for adolescents and young adults. Team-based learning (TBL) is an evidence-based teaching paradigm that may result in greater PSS among students. Objective: We compared PSS reported by students taught using TBL and non-TBL methods. Method: We measured PSS at the end of three different semesters from face-to-face and online courses. Results: TBL students reported experiencing more PSS than non-TBL students. Teaching Implications: Given the positive outcomes of TBL, more instructors should consider adopting TBL.