The dangers of organic dye pollutants and environmental pollution improvement through photocatalytic degradation are important courses in applied chemistry programs in universities. Zinc oxide (ZnO)-based nanomaterials are potent catalytic agents against organic dyes, but few experiments are available for students to understand their role and mechanism in class. Herein, we designed a comprehensive experiment across 24 class hours for undergraduates to investigate the photodegradation of colored organic dyes, including methylene blue, methyl orange, methyl violet, rhodamine B, basic fuchsin, and thymolphthalein, by a nanocomposite composed of ZnO-coated graphene oxide (ZnO/GO). This nanomaterial was prepared using a facile heating reflux method within 1 h. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction were introduced to students to characterize the synthesized products. Students could observe the time- and dose-dependent degradation as well as the reusability of ZnO/GO. Additionally, the addition of t-butanol, benzoquinone, and triethanolamine, scavengers of hydroxyl radical ([superscript .]OH), superoxide anion ([superscript .]O[superscript 2-]), and hole (h[superscript +]), respectively, to the degradation system allowed them to master the underlying catalytic mechanism of ZnO/GO. This experiment improves students' understanding of the photocatalytic effect of ZnO nanomaterials and stimulates them to engage in the field of applied chemistry and thus is worth recommending to undergraduates.