The doctrine of informed consent has been enumerated to protect the rights of human subjects involved in biomedical research. The elements of informed consent are summarized along with the changes of emphasis that have evolved. The issue of liability and means for minimizing its impact are discussed. (Author/MLW)

Two federal agencies proposed conflict-of-interest guidelines that would require scientists supported by government money to file financial-disclosure forms and universities to review those forms and eliminate conflicts of interest. The National Institutes of Health and the Alcohol, Drug Abuse, and Mental Health Administration proposed the…

Describes the development of a Unified Medical Language System (UMLS) by the National Library of Medicine that will retrieve and integrate information from a variety of information resources. Highlights include the metathesaurus; the UMLS semantic network; semantic locality; information sources map; evaluation of the metathesaurus; future…

Participants in the January 1999 Internet World Conference on Biomedical Sciences will meet and communicate solely in cyberspace. In many respects, the conference will be traditional, with 56 symposia on 15 biomedical subjects, but participants avoid registration fees and travel costs. Japanese universities conducted four previous conferences,…

Describes a laboratory protocol optimizing the conditions for the assay of pepsin activity using the Coomasie Blue dye binding assay of protein concentration. The dye bonds through strong, noncovalent interactions to basic and aromatic amino acid residues. (DDR)

Discusses applications of recombinant DNA technology and the controversies surrounding that technique. Provides a cooperative learning project idea that involves teams of students investigating and debating these issues. (DDR)

The debate over whether there is an oversupply of doctorates in the biomedical sciences is examined, and a case study of doctoral graduates and postdoctoral fellows at the Tulane University (Louisiana) Medical Center is reported. It is concluded that there is no biomedical doctoral glut and that doctoral program downsizing would have serious…

Addresses the problem of how to find interesting but previously unknown implicit information within the scientific literature. The use of software, called Arrowsmith, that can create suggestive juxtapositions of Medline records to help biomedical researchers detect new and useful relationships, is described. Contains 34 references. (Author/MES)

In recent years, microarray analysis has become a key experimental tool, enabling the analysis of genome-wide patterns of gene expression. This review approaches the microarray revolution with a focus upon four topics: 1) the early development of this technology and its application to cancer diagnostics; 2) a primer of microarray research,…

There is increasing pressure, both from institutions central to the national scientific mission and from regional and national accrediting agencies, on natural sciences faculty to move beyond course examinations as measures of student performance and to instead develop and use reliable and valid authentic assessment measures for both individual…

Controlled experiments were conducted with an enhanced experimental intermediary system, CONIT (COnnector for Networked Information Transfer), to test how effective such a system could be in assisting end users in online searching of medical and biomedical literature. A total of 16 end users, none of whom had previously operated CONIT or any of…

In 1988, Harvard University unveiled plans for Medical Science Partners (MSP), a venture capital fund intended to invest in and commercialize faculty biomedical projects. Critical of what is perceived as a "15 year long trend" wherein Harvard has "forged deeper and more extensive ties with the biomedical industry," the document…

This is the first of three volumes which presents the Committee on Biomedical and Behavioral Research Personnel's examination of the educational process that leads to doctoral degrees in biomedical and behavioral science (and to postdoctoral study in some cases) and the role of the National Research Service Awards (NRSA) training programs in it.…

Volume Three of the Biomedical and Behavioral Research Scientists study contains five commissioned papers. The first paper, "Evaluating the National Research Service Award Program (NRSA): A Review and Recommendations for the Future," (Georgina M. Pion) reviews previous evaluation activities of the NRSA program and proposes an agenda describing the…

The National Institute on Aging (NIA) has, for the past several years, focused attention on a wide range of clinical problems associated with aging, including falls and gait disorders, bone fractures, urinary incontinence, and hypertension. Understanding the causes of and exploring possible treatments for Alzheimer's disease has been another of…