An integrated multi-tiered system of support (I-MTSS) framework facilitates the implementation of practices across academic, social, emotional, and behavioral wellness (SEB) areas. Integrated multi-tiered systems of support allow schools to support all students efficiently and effectively in a manner that best meets their comprehensive needs. This approach is especially critical for students with multiple or complex learning and SEB needs. Although there is great promise in improving the effectiveness and efficiency of supporting students through an I-MTSS model, there is a need to help educators understand how an integrated approach can be practically implemented. In this article, we share information on practical applications of I-MTSS that can be implemented in elementary school settings. [This is the online version of an article published in "Intervention in School and Clinic."]