Objective: The current study examined the extent to which pandemic-specific psychological distress symptoms and perceived stress were associated with sleep difficulties among college students. Participants: Participants included 203 full-time undergraduates from a medium-sized university located in the U.S. Methods: A survey was administered online in December of 2020. Results: Regression analyses showed pandemic-specific psychological distress was associated with the three sleep difficulties. Perceived stress was also associated with these three sleep difficulties of falling asleep (B = 0.078, SE = 0.013, p = 0.000), difficulty staying asleep (B = 0.080, SE = 0.014, p = 0.000), and with waking too early (B = 0.043, SE = 0.014, p = 0.003), and mediated the relationship between psychological distress and each of the sleep difficulties. Conclusions: During public health emergencies health promotion strategies to promote sleep health should include psychoeducational strategies specifically addressing pandemic-specific psychological distress symptoms and perceived stress.