The goal of this dissertation was to find converging evidence from behavioral and neuroimaging analyses of the mechanisms of orthographic integration with general language processes. By examining orthography effects, covert influences of orthography on non-written tasks, in participants with aphasia, we attempt to elucidate the nature of…

Sentence comprehension requires both syntactic prediction and working memory processes. Evidence suggests that both are impaired in agrammatic aphasia, and can independently contribute to comprehension breakdowns, but the relationship between them, especially during real-time sentence comprehension remains unclear. Two EEG studies investigated…

Background: Gesture and speech collaborate in conveying meaning, and gesture is often leveraged by people with neurogenic communication disorders, such as aphasia, cognitive-communicative impairments and primary progressive aphasia, when words fail them. Because gesture is imagistic, transitory and holistic, there are inherent challenges when…

Background: The term progressive apraxia of speech (PAOS) is used to describe speakers presenting with isolated or dominant apraxia of speech in the context of a neurodegenerative syndrome, including primary progressive apraxia of speech (PPAOS) and dominant progressive apraxia of speech (DAOS), respectively. Its motor speech profile has been…

Neuromyelitis optica spectrum disorder (NMOSD) is an acquired neurological disorder primarily affecting physical and visual functioning. There is a lack of empirical evidence in the existing literature about the nature of speech, language, and cognitive deficits associated with NMOSD. Hence, this case study provides assessment information about a…

Purpose: This study investigated conflict adaptation in aphasia, specifically whether upregulating cognitive control improves sentence comprehension. Method: Four individuals with mild aphasia completed four eye tracking sessions with interleaved auditory Stroop and sentence-to-picture matching trials (critical and filler sentences). Auditory…

Background: People with aphasia (PWA) typically exhibit deficits in spoken discourse. Discourse analysis is the gold standard approach to assess language deficits beyond sentence level. However, the available discourse assessment tools are biased towards English and European languages and Western culture. Additionally, there is a lack of consensus…

Rett syndrome (OMIM #312750) is a progressive neurodevelopmental disease with clinical manifestations including loss of spoken language and apraxia. We summarized per PRISMA guidelines findings on their non-verbal social skills. Twelve studies (n = 479 females, 1.6-52 years) were sorted into a (non-)interventional design including video-coding,…

Background: Aphasia, a common consequence of stroke, which affects both communication and social functioning, and in turn, quality of life, is on the rise due to increases in stroke prevalence and survival rate. The rehabilitation of post-stroke aphasia primarily falls within the purview of speech-language pathology and research supports the…

Background: Endovascular clot retrieval (ECR) is known to reduce global disability at 3 months post stroke however limited research exists regarding the trajectory of specific clinical impairments including language, swallowing and cognitive deficits between onset and 3 months. Aims: To assess language, swallowing, and cognitive performance…

Background: Stroke care in the UK was significantly affected by the COVID-19 pandemic, with many services switching to telehealth. Post-pandemic, a UK survey of speech and language therapists (SLTs) working with people with aphasia (PWA) showed the vast majority planned to continue to use telehealth alongside in-person intervention. Telehealth is…

Purpose: Emotional stimuli have been shown to influence language processing (both language comprehension and production) in people with aphasia (PWA); however, this finding is not universally reported. Effects of emotional stimuli on language performance in PWA could have clinical and theoretical implications, yet the sparsity of studies and…

Background: Humans often use co-speech gestures to promote effective communication. Attention has been paid to the cortical areas engaged in the processing of co-speech gestures. Aims: To investigate the neural network underpinned in the processing of co-speech gestures and to observe whether there is a relationship between areas involved in…

Purpose: Increasingly, mechanisms of learning are being considered during aphasia rehabilitation. Well-characterized learning mechanisms can inform "how" interventions should be administered to maximize the acquisition and retention of treatment gains. This systematic scoping review mapped hypothesized mechanisms of action (MoAs) and…

An intraverbal assessment was administered to older adults with aphasia, using a hierarchy of questions that required increasingly complex verbal discriminative stimulus control. Five categories of errors were defined and analyzed for putative stimulus control, with the aim to identify requisite assessment components leading to more efficient and…