In an 8-week double-blind comparison, haloperidol reduced the severity of the target symptoms impulsiveness, hostility, and aggressiveness in significantly more mentally retarded children than did chlorpromazine. (Author)

Analyzed were serum levels of IgA, IgG, ad IgM in groups of institutionalized and noninstitutionalized Down's syndrome subjects and in institutionalized retarded children with other etiologies. (KW)

A comparison of plasma (pseudo) cholinesterase and erythrocyte (true) cholinesterase activity in 16 male childhood schizophrenic patients and 16 male nonpsychotic hospitalized controls revealed no significant differences between the two groups. (Author)

Relying upon grant-supported salaries, many medical schools have greatly expanded their faculties; but if new funding devices are not discovered, retrenchment will occur. Physicians, who are trained to look at the big picture, must continue to be an essential element in the biomedical research team. (MLW)

The regulations prescribed by the Department of Health, Education, and Welfare regarding human subjects research are examined including their effects on research procedures. (MM)

This study investigated whether blood plasma levels of pro-opiomelanocortin-derived (POMC) peptides, beta-endorphin-like activity, adrenocorticotrophic hormone, and adrenal cortisol immediately after self injurious behavior (SIB) episodes predicted subsequent response to an opiate blocker in 10 patients with mental retardation. Results suggest…

Analyzes the currency of the information found on SilverPlatter's Medline CD-ROM. Results show that the currency of information can vary tremendously. Priority level, periodicity, and prior database were found to have a low but highly significant influence on currency. Six tables and nine figures show results. (Author/AEF)