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Guegan, Jean-Paul; Daniellou, Richard – Journal of Chemical Education, 2012
NMR spectroscopy is a powerful tool for characterizing and identifying molecules and nowadays is even used to characterize complex systems in biology. In the experiment presented here, students learned how to apply this modern technique to probe interactions between small molecules and proteins. With the use of simple organic synthesis, students…
Descriptors: Organic Chemistry, Science Instruction, College Science, Science Laboratories
Carroll, Anne-Marie; Kavanagh, David J.; McGovern, Fiona P.; Reilly, Joe W.; Walsh, John J. – Journal of Chemical Education, 2012
Nature is a well-recognized source of compounds of interest, but access is often an issue. One pertinent example is the cinchona alkaloids from the bark of "Cinchona calisaya." In this experiment, students at the third-year undergraduate level undertake the selective isolation and characterization of two of the four main alkaloids present in the…
Descriptors: Science Experiments, Chemistry, Science Instruction, College Science
Yu, Pulan – ProQuest LLC, 2012
Classification, clustering and association mining are major tasks of data mining and have been widely used for knowledge discovery. Associative classification mining, the combination of both association rule mining and classification, has emerged as an indispensable way to support decision making and scientific research. In particular, it offers a…
Descriptors: Databases, Classification, Data Collection, Chemistry
Leslie, Ray; Leeb, Elaine; Smith, Robert B. – Journal of Chemical Education, 2012
A series of laboratory experiments that complement a medicinal chemistry lecture course in drug design and development have been developed. The synthesis of ethyl nalidixate covers three separate experimental procedures, all of which can be completed in three, standard three-hour lab classes and incorporate aspects of green chemistry such as…
Descriptors: Chemistry, Laboratory Experiments, Science Instruction, Pharmacology
Thomas, Alyssa C.; Boucher, Michelle A.; Pulliam, Curtis R. – Journal of Chemical Education, 2015
Our Introduction to Research Methods course is a first-year majors course built around the idea of helping students learn to work like chemists, write like chemists, and think like chemists. We have developed this course as a hybrid hands-on/ lecture experience built around instrumentation use and report preparation. We take the product from one…
Descriptors: Qualitative Research, Statistical Analysis, Research Methodology, Methods Courses
Jacobs, Danielle L.; Dalal, Heather A.; Dawson, Patricia H. – Journal of Chemical Education, 2016
To develop information literacy skills in chemistry and biochemistry majors at a primarily undergraduate institution, a multiyear collaboration between chemistry faculty and librarians has resulted in the establishment of a semester-long capstone project for Organic Chemistry II. Information literacy skills were instilled via a progressive…
Descriptors: Science Instruction, Chemistry, Organic Chemistry, College Science
Jacobs, Danielle L.; Dalal, Heather A.; Dawson, Patricia H. – Journal of Chemical Education, 2016
The impetus to incorporate instruction on the efficient and responsible practice of chemical information literacy into the undergraduate chemistry curriculum has become exceptionally urgent. At Rider University, Chemical Information Instruction (CII) has accordingly evolved from face-to-face sessions into online modules to embed information…
Descriptors: Science Instruction, Chemistry, Organic Chemistry, College Science
Scahill, Lawrence; Hallett, Victoria; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Tierney, Elaine; Deng, Yanhong; Dziura, James; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2013
There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to…
Descriptors: Autism, Pharmacology, Effect Size, Pervasive Developmental Disorders
Brackney, Ryan J.; Cheung, Timothy H. C.; Neisewander, Janet L.; Sanabria, Federico – Journal of the Experimental Analysis of Behavior, 2011
Dissociating motoric and motivational effects of pharmacological manipulations on operant behavior is a substantial challenge. To address this problem, we applied a response-bout analysis to data from rats trained to lever press for sucrose on variable-interval (VI) schedules of reinforcement. Motoric, motivational, and schedule factors (effort…
Descriptors: Intervals, Reinforcement, Behavior, Operant Conditioning
Schurter, Eric J.; Zook-Gerdau, Lois Anne; Szalay, Paul – Journal of Chemical Education, 2011
This general chemistry laboratory uses differences in solubility to separate a mixture of caffeine and aspirin while introducing the instrumental analysis methods of GCMS and FTIR. The drug mixture is separated by partitioning aspirin and caffeine between dichloromethane and aqueous base. TLC and reference standards are used to identify aspirin…
Descriptors: Spectroscopy, Chemistry, Science Instruction, Science Laboratories
Clay, Matthew D.; McLeod, Eric J. – Journal of Chemical Education, 2012
Salicylic acid and its derivative, acetylsalicylic acid, are often encountered in introductory organic chemistry experiments, and mention is often made that salicylic acid was originally isolated from the bark of the willow tree. This biological connection, however, is typically not further pursued, leaving students with an impression that biology…
Descriptors: Organic Chemistry, Science Instruction, College Science, Science Experiments
Battle, Gary M.; Allen, Frank H. – Journal of Chemical Education, 2012
A clear understanding and appreciation of noncovalent interactions, especially hydrogen bonding, are vitally important to students of chemistry and the life sciences, including biochemistry, molecular biology, pharmacology, and medicine. The opportunities afforded by the IsoStar knowledge base of intermolecular interactions to enhance the…
Descriptors: Interaction, Chemistry, Biological Sciences, Biochemistry
Shahidullah, Jeffrey D. – Communique, 2012
Psychotropic medications are increasingly used to treat children and adolescents with mental health conditions. Between the years 1994 and 2001, there was a 191.7% increase in number of office visits resulting in a psychotropic medication prescription among children and adolescents. Many drugs are prescribed to children "off-label", whereby they…
Descriptors: Drug Therapy, Mental Health, Children, Adolescents
Phadtare, Sangita; Abali, Emine; Brodsky, Barbara – Biochemistry and Molecular Biology Education, 2013
For successful delivery of basic science topics for health-professional students, it is critical to reduce apprehension and illustrate relevance to clinical settings and everyday life. At the beginning of the Biochemistry course for Physician Assistants, a team-based assignment was designed to develop an understanding of the mechanism of action,…
Descriptors: Drug Use, Biochemistry, Science Instruction, Science Activities
Troisi, Joseph R., II – Psychological Record, 2011
Operant extinction contingencies can undermine the discriminative stimulus effects of drugs. Here, nicotine (0.4 mg/kg) and ethanol (0.8 g/kg) first functioned as either an S[superscript D] or S[superscript Delta], in a counterbalanced one-lever go/no-go (across sessions) operant drug discrimination procedure. Pavlovian extinction in the training…
Descriptors: Narcotics, Classical Conditioning, Animals, Drug Use