Portland Public Schools (PPS), the largest school district in Oregon, serves more than 46,000 students in regular and special programs. More than 2,900 classroom teachers address the needs of a diverse student population (44% minority, 46% low income, 14% special education, 9% English language learners). A district needs assessment in fall 2005 revealed that 13 of Portland's 85 regular schools were eligible to participate in the Striving Readers program. Four of the high schools and 5 of the middle schools determined that they could meet the program's research requirements. All 9 schools had at each grade level a significant number of students who were at least 2 years behind in reading achievement; all received Title I funding; and none had achieved Adequate Yearly Progress under No Child Left Behind at the time of the Striving Readers application. School leaders expected the Striving Readers program to impact more than 6,400 students and 450 teachers in the 9 participating schools. After examining adolescent reading programs and studying the research on adolescent literacy, Portland Public Schools selected the Strategic Instruction Model Content Literacy Continuum developed by the University of Kansas' Center for Research on Learning to improve teacher instruction and student reading achievement in the participating middle and high schools. This report summarizes Year 1 (2006-2007), Year 2 (2007-2008), Year 3 (2008-2009), Year 4 (2009-2010), and Year 5 (2010-2011) of implementation of the targeted intervention for students reading at least 2 years below grade level in Grades 7-10 and the whole school intervention designed to help all students in Grades 6-12 learn the critical content in all curricular areas.