Increasing numbers of underprepared students are admitted to colleges and universities with aspirations of earning a degree in a science, technology, engineering, or mathematics (STEM) discipline. Transitioning to college is difficult for all students, but can be especially challenging for the underprepared STEM student. Many of these students are capable of completing STEM degrees if given additional support during their first-year advising sessions as well as opportunities to strengthen their foundational knowledge prior to enrolling in major-level course work. Pathways Leading to Undergraduate Success in the Sciences (PLUSS) is an intrusive advising program the University of Southern Indiana designed to provide at-risk undergraduate STEM majors with increased academic support. The PLUSS program is associated with increased retention rates.