The National Science Foundation (NSF)-funded Urban College (UC) Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM) program was designed to comprehensively support academically talented low-income students. The program served 45 students between the fall semesters of 2012 and 2015. The primary goals of the program were increasing participant's retention, success, and completion. Program components included a scholarship award of $3,500 per semester for up to four semesters; authentic experiences such as internships and undergraduate research; assignment of and regular interaction with a faculty mentor; laboratory or industry mentoring; free tutoring services; customized academic advisement; virtual cohort participation; presentations of research; and a student support coordinator. A retrospective, quasi-experimental comparison study of the UC S-STEM program was performed. Statistical analysis utilizing Pearson's chi-square, and independent t-tests evidenced statistically significantly higher rates in student success, progress, and cumulative GPA in the group of students who received the program as an intervention and a comparison group of students, matched on previously reported measures of success, who did not receive the intervention. Further, on the progress rate metric, a within-subjects t-test comparison evidenced statistically significantly higher rates in students after the intervention than before. The evidence presented supports the efficacy of the UC S-STEM program in increasing student progress rate for credits earned, cumulative GPA, and success. Recommendations include designing STEM support programs that include authentic experiences, mentoring, cohort experiences; allocating adequate resources to these programs; and adapting the analytical process used in this study to other, similar programs as one component of programmatic assessment. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]