The COVID-19 pandemic brought unprecedented economic and policy challenges to the United States and other countries. Navigating out of the pandemic slowdown is another novel experience, which makes it more difficult to answer the question addressed each year in the "State of Working Pennsylvania": How is the Pennsylvania economy performing from the perspective of working people? Is Pennsylvania about to enter a recession brought on by Federal Reserve interest rate hikes? Will inflation persist and erode real wages or will inflation decline quickly while real wages grow? Will the recent shrinkage of the Pennsylvania labor force--the "Great Resignation"--result in an enduring and long overdue increase in workers' power relative to employers in the labor market? This year's report contains sections on the following topics: (1) The State of the Pennsylvania Economy; (2) The State of the Pennsylvania Labor Market--How Great the Resignation?; (3) The State of Wage Growth in Pennsylvania; (4) The State of Pennsylvania's Low-Wage Labor Market; (5) The State of Corporate Profits and Inflation; (6) The State of Unions in Pennsylvania; and (7) Policy: Door Number One or Door Number Two. [For the 2021 report, see ED624089.]