As quantum information science and technology (QIST) is becoming more prevalent and occurring not only in research labs but also in industry, many educators are considering how best to incorporate learning about quantum mechanics into various levels of education. Although much of the focus has been on quantum concepts in nonlab courses, current…

During the COVID-19 pandemic and subsequent lockdown, both schools and universities faced significant challenges in moving teaching from an in-situ setting to a remote one, this included laboratory experiments. This paper presents an experiment developed to use a phone's in built pressure sensor, common to most smart phones. By using this sensor…

The [2 + 2] photocycloaddition reaction of olefins is an effective, atom-economical approach to produce cyclobutane compounds in organic synthetic chemistry, and they usually exhibit high regioselectivity and stereoselectivity. Here we devised a solid-state [2 + 2] photocycloaddition experiment that introduces senior undergraduate students with…

A student experiment that uses QuEChERS (quick, easy, cheap, effective, rugged, and safe) methodology for extraction and HPLC for quantitative determination of tocopherols from seeds and nuts is described here. Chromatographic separation is achieved by using a pentafluorophenyl stationary phase which gives enhanced separation of the tocopherols…

A new undergraduate organic laboratory experiment has been developed and implemented for the Ugi three-component synthesis of the topical anesthetic lidocaine with excellent atom economy. Paraformaldehyde, diethylamine, and 2,6-dimethylphenyl isocyanide were combined and conveniently stirred at room temperature for a week in methanol with acetic…

Mercury beating heart (MBH) is a well-known demonstration of redox processes. However, the development and application of the MBH system are significantly restricted due to its safety issues. Here, a direct current electric field-enabled gallium-based liquid metal heartbeat in a salt solution or alkaline solution is introduced as a demonstration…

A new undergraduate organic laboratory experiment has been developed for amide bond formation between biorenewable 2-furoic acid and either of two substituted piperazines to prepare medicinally relevant amide products using a procedure with industrial significance. The reactions proceeded smoothly under ambient conditions using the combination of…

A fast, operationally simple, and reproducible synthetic protocol for anthraquinone dyes (AQDs), suitable for upper-division undergraduate industrial and organic chemistry laboratory courses, has been developed. This experiment is composed of three stages; the first step deals with the synthesis of AQDs, followed by a purification step, and…

An introductory normal phase column chromatography experiment is described and evaluated for second year undergraduate chemistry laboratory class. The experiment involves a nucleophilic substitution yielding a crude mixture of reactant and one product, both of which are brightly colored and contrasting, creating a clearly visual separation when…

A drug discovery project has been successfully implemented in an advanced undergraduate organic chemistry laboratory. In the laboratory, a five-step synthetic sequence is used to prepare five analogues of 13-phenyl-1-tridecanol. These compounds are key precursors in the synthesis of 2-oxo-14-phenyltetradecanes. This class of compounds, isolated…

The use of a multicompartment electrochemical cell for the potentiometric determination of solubility product constants of aqueous I[superscript -], Br[superscript -], SCN[superscript -], and Cl[superscript -] salts of silver is presented. An electrochemical cell presented in this study contained multiple half-cells made of disposable drinking…

The implementation of a laboratory exercise in an undergraduate chemistry course, where students perform a comparison of three different synthetic methods toward [Cu(Cl)(IPr)]-complexes (IPr = N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), is described. The students are introduced to the continuous improvement of reactions in terms of green…

Food safety science is an important field due to its practical applications in maintaining public safety and confidence in consumer goods. A significant component of food safety science is the detection and regulation of heavy metals in food. Heavy metals such as mercury (Hg) are of particular concern because of their potential to damage the…

The practical two-step synthesis of 1-phenylthiourea is reported here as an undergraduate experiment for the organic synthesis laboratory. The reactions involved in 1-phenylthiourea preparation are very useful didactic examples to illustrate concepts relating to carbonyl substitution and addition, the effect of pH on solubility of organic…

Accuracy and precision are measures of experimental error and are fundamental to most chemical analysis laboratory classes. Assessment of accuracy and precision is often based on the comprehension of the results generated by students rather than on the quality of the data generated. This activity focused on developing a chemical analysis…