A Maker-oriented experimental course in general chemistry has been created by using digital tools, such as a computer, a pressure sensor, and data processing software, in combination with a new multiple expansion method and laboratory equipment to determine the vapor pressure precisely. In this Maker chemistry experiment, the pressure sensor measures the pressure inside the chamber and sends the measured pressure value to the microcontroller, which offers a much cheaper and safer alternative than the current triple expansion method while avoiding its inconvenience and frequent failure. Graphing with Origin software provides students with the hands-on experience to appreciate significant chemistry concepts, preparing them for delving further into the subject using data processing software in a scientific inquiry activity. In the multiple expansion method, about 20 sets of data are measured and then processed for data fitting so that more accurate values of vapor pressure and molar heat of evaporation can be obtained, allowing for the better engagement of both first-year undergraduate and high school students.