The study aims to determine the impact of blended learning on the performance of science students and their self-regulation and to identify effective recommendations to improve the effectiveness of blended learning. Third-year students of Kazan Federal University took part in the study. The measurement scale tools adopted in this study included pre-test, post-test and self-regulation questionnaires. Analyses showed that participants in the experimental group scored higher on the final test than students in the reference group. The experimental group scored significantly higher than the reference group on the self-regulation questionnaire. It can be concluded that the blended learning model can significantly improve students' self-regulation compared to the traditional approach to learning. Recommendations were made to improve blended learning.