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Saba, Shahrokh; Ciaccio, James A. – Journal of Chemical Education, 2016
While orthoesters are often used by chemists as alkylating, acylating, and formylating agents, they are rarely encountered in introductory organic chemistry curricula. We describe a second-semester organic chemistry laboratory experiment in which students acetylate unknown amine hydrochloride salts with trimethyl orthoacetate (TMOA) in the absence…
Descriptors: Organic Chemistry, Introductory Courses, Laboratory Experiments, Scientific Concepts