ERIC Number: EJ1294841
Record Type: Journal
Publication Date: 2021-Apr
Pages: 14
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1072-0502
EISSN: N/A
Available Date: N/A
Medial Prefrontal Cortex and Hippocampal Activity Differentially Contribute to Ordinal and Temporal Context Retrieval during Sequence Memory
Reeders, Puck C.; Hamm, Amanda G.; Allen, Timothy A.; Mattfeld, Aaron T.
Learning & Memory, v28 n4 p134-147 Apr 2021
Remembering sequences of events defines episodic memory, but retrieval can be driven by both ordinality and temporal contexts. Whether these modes of retrieval operate at the same time or not remains unclear. Theoretically, medial prefrontal cortex (mPFC) confers ordinality, while the hippocampus (HC) associates events in gradually changing temporal contexts. Here, we looked for evidence of each with BOLD fMRI in a sequence task that taxes both retrieval modes. To test ordinal modes, items were transferred between sequences but retained their position (e.g., AB3). Ordinal modes activated mPFC, but not HC. To test temporal contexts, we examined items that skipped ahead across lag distances (e.g., ABD). HC, but not mPFC, tracked temporal contexts. There was a mPFC and HC by retrieval mode interaction. These current results suggest that the mPFC and HC are concurrently engaged in different retrieval modes in support of remembering when an event occurred.
Descriptors: Memory, Brain Hemisphere Functions, Diagnostic Tests, Task Analysis, Sequential Learning, Accuracy, Item Analysis
Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A
Author Affiliations: N/A