This study aims to examine the relationship between psychological resilience and interpersonal communication skills of university students. The study group consisted of 544 female (272) and male (272) university students with normal development attending the Faculty of Health Sciences of 5 different universities in Ankara in the 2022-2023 academic year. Brief Resilience Scale and Interpersonal Communication Competence Inventory were used as data collection tools. The data obtained showed that there was a statistically significant difference between male and female participants in terms of psychological resilience. The study shows that males scored higher on the resilience scale than females. This result is in line with the belief that females are "more vulnerable" and "less psychologically resilient" than males. It also shows that there is no relationship between a higher degree of resilience and social support system. This study aims to motivate university students to strengthen their resilience and communication skills for better service.