Solitude may often be confused with the concept of loneliness and perceived as a negative experience. However, when solitude is a choice, it can be a growth-creating and healing experience. In this study, a model examining the mediating role of mindfulness in the relationship between the preference for solitude and life satisfaction among university students was tested. A total of 261 university students participated in the study. A personal information form, the Preference for Solitude Scale, the Mindfulness Scale, and the Life Satisfaction Scale were employed to collect data. Results indicated that mindfulness was a significant mediator in the preference for solitude and life satisfaction link.