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Chu, Haitao2
Siegel, Lianne2
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RIMeta: An R Shiny Tool for Estimating the Reference Interval from a Meta-Analysis
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Jiang, Ziren; Cao, Wenhao; Chu, Haitao; Bazerbachi, Fateh; Siegel, Lianne – Research Synthesis Methods, 2023
A reference interval, or an interval in which a prespecified proportion of measurements from a healthy population are expected to fall, is used to determine whether a person's measurement is typical of a healthy individual. For a specific biomarker, multiple published studies may provide data collected from healthy participants. A reference…
Descriptors: Intervals, Computation, Meta Analysis, Measurement
Estimating the Reference Interval from a Fixed Effects Meta-Analysis
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Cao, Wenhao; Siegel, Lianne; Zhou, Jincheng; Zhu, Motao; Tong, Tiejun; Chen, Yong; Chu, Haitao – Research Synthesis Methods, 2021
A reference interval provides a basis for physicians to determine whether a measurement is typical of a healthy individual. It can be interpreted as a prediction interval for a new individual from the overall population. However, a reference interval based on a single study may not be representative of the broader population. Meta-analysis can…
Descriptors: Meta Analysis, Statistical Analysis, Intervals, Computation