A broadly applicable semester-long course-based undergraduate research experience (CURE)-inspired organic II laboratory course was developed from an engaging story supported by the current literature surrounding paraben use in consumer products. The project involves the synthesis of brominated parabens followed by an investigation into the…

In at least two papers published in this "Journal," enzyme free energy diagrams were presented showing enzyme--substrate binding to be nonspontaneous. I present here several different approaches showing that enzyme--substrate binding is "always" spontaneous, and the y-axis of the reaction progress diagrams presented previously…

The use of approximations in solving problems in sciences can be vital for students. Order of magnitude estimation also helps with physical understanding of the quantities involved in a calculation. For example, in the first exam in a first-year class in chemistry the student must find the mass in grams of an atom; a couple of students will…

Enzymes are organic molecules known for their catalytic nature because they accelerate metabolic reactions in organisms. The study of enzyme functions and modes of action is essential to understand Biochemistry. This study aimed to analyse the acetylcholinesterase enzymatic activity, as well as the enzymatic inhibition mechanism in practical…

The static equilibrium properties of a spool, resting on an incline and subject to the tension exerted by a string wrapped around the core cylinder, are studied by means of Newtonian mechanics. The overall behaviour of this system is imagined to be similar to that of a doggie kept on a leash. Starting from the well-known mechanical properties of…

A new undergraduate organic laboratory experiment has been developed and implemented for the Ugi three-component synthesis of the topical anesthetic lidocaine with excellent atom economy. Paraformaldehyde, diethylamine, and 2,6-dimethylphenyl isocyanide were combined and conveniently stirred at room temperature for a week in methanol with acetic…

Mercury beating heart (MBH) is a well-known demonstration of redox processes. However, the development and application of the MBH system are significantly restricted due to its safety issues. Here, a direct current electric field-enabled gallium-based liquid metal heartbeat in a salt solution or alkaline solution is introduced as a demonstration…

Recently, two-dimensional (2D) nanostructures, such as graphene and few-layer MoS[subscript 2], have been applied to wide fields based on their intriguing performances, and they contribute to developments of clean energy, biomedicine, and environmental protection. The synthesis of 2D nanostructures involves chemistry, materials, and…

This undergraduate laboratory experiment is designed for first-year general chemistry students with the goal of introducing the brilliant colors and magnetic properties of transition metal complexes within a bioinorganic/cell biology context. In the first laboratory period, a coordination complex formed from ferric chloride and maltol is…

A new undergraduate organic laboratory experiment has been developed for amide bond formation between biorenewable 2-furoic acid and either of two substituted piperazines to prepare medicinally relevant amide products using a procedure with industrial significance. The reactions proceeded smoothly under ambient conditions using the combination of…

A new method to determine a ternary phase diagram of benzene-acetic acid-water system is provided to upper-division undergraduate students. The partially miscible liquid phase region can be accurately constructed using isothermal titration microcalorimetry (ITC). Compared with the traditional visual method, ITC can provide precise data and more…

As quantum information science and technology (QIST) is becoming more prevalent and occurring not only in research labs but also in industry, many educators are considering how best to incorporate learning about quantum mechanics into various levels of education. Although much of the focus has been on quantum concepts in nonlab courses, current…

An integrated inorganic chemistry laboratory experience focusing on heterogeneous electrocatalysis with nickel (Ni)- and cobalt (Co)-based electrocatalysts is designed for upper-division, major-level chemistry students. In this laboratory, students will be guided through the fabrication of an indium tin oxide (ITO)-coated glass working electrode,…

The [2 + 2] photocycloaddition reaction of olefins is an effective, atom-economical approach to produce cyclobutane compounds in organic synthetic chemistry, and they usually exhibit high regioselectivity and stereoselectivity. Here we devised a solid-state [2 + 2] photocycloaddition experiment that introduces senior undergraduate students with…

This laboratory exercise integrates chemistry and biology concepts to give third/fourth-year undergraduate students an opportunity to apply knowledge from different subject areas to address a real-world biomedical issue such as pathogen inhibition using composite materials. It involves the preparation of a bacteria-derived cellulosic biopolymer…