The chemistry of 4d and 4f metals was investigated at the undergraduate level in an effort to incorporate f-element chemistry in the curriculum. This was accomplished through microwave-assisted synthesis of 1,10-phenanthroline (phen) coordination compounds [Eu(phen)(subscript 3)](PF[subscript 6])[subscript 3] and [Ru(phen)(subscript…

Electrochemistry is taught in most undergraduate chemistry programs. Although this topic is important for students due to its broad interest in industry (energy, diagnostics, car industry, etc.), they often find it difficult, because it is based on a combination of various physical concepts such as electric fields, interfacial processes or charge…

A discovery-based experiment for the synthesis of arylpropiolic acids via carboxylation of arylacetylenic Grignard reagents was developed. This experiment shows the "dual utility" of Grignard reagents. In the synthesis of arylpropiolic acids reported here, we have demonstrated the use of a Grignard reagent as a base in a "Grignard…

Organic electrode materials are progressively becoming a research hotspot for energy storage materials due to their renewable and environmentally friendly features. Inspired by the energy transduction mechanism of flavin adenine dinucleotide (FAD) on the inner mitochondrial membrane of living organisms, the lithium storage electrochemical behavior…

An undergraduate laboratory experiment has been developed for the synthesis of a reactive cross-linker that is useful in various highly visual demonstrations of organic reactivity, click chemistry, and biobased polymer synthesis. A triazolinedione-based cross-linker, which is known as a useful reagent for click chemistry, can be obtained from…

An efficient synthesis of the exorbitantly priced Lambert-Eaton myasthenic syndrome drug amifampridine was developed and applied in the second-semester undergraduate organic chemistry laboratory. The two-step synthesis entails a nucleophilic aromatic substitution reaction of commercial 4-chloro-3-nitropyridine with methanolic ammonia to afford…

The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a "gem"-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of "gem"-diols…

A [beta]-lactam, the core structure unit of clinically important antibiotics such as penicillin and cephalosporin, is one of the most commonly encountered four-membered heterocycles in organic chemistry and is widely used in medicine and biochemistry. The Kinugasa reaction, a copper­(I)-catalyzed cycloaddition of a terminal alkyne with a nitrone,…

Apurinic/apyrimidinic (AP or abasic) sites are deoxyribonucleic acid (DNA) lesions that result from the loss of a nucleobase by hydrolysis of the "N"-glycosyl bond. AP sites are the most frequent lesions in cells and are caused by environmental and cancer therapeutic genotoxins. Herein, the bicinchoninic colorimetric assay, typically…

The trajectory of a ball rolling across an inclined plane was recorded on video film to determine if it followed a parabolic path as others have suggested. The challenges in this case were (a) to determine the magnitude and direction of the friction force on the ball, (b) to determine the effect of the friction force on the trajectory and (c) to…

Blue (B), yellow (Y), red (R), and green (G) color-changing dye was used in a general chemistry course for first-year undergraduate students with nonscience majors to highlight the redox reactions written as the gain and loss of hydrogen. The first experiment is a vibrant color variation using a synthetic dye of indigo carmine. The second…

At the undergraduate level, the composite motion of simple harmonic vibrations has always been the main content of physics as well as several other scientific disciplines. Many textbooks tell us clearly that when the frequency ratio [omega][subscript 1]/[omega][subscript 2] of two perpendicular vibrations is simple integer ratio n[subscript…

Visual representations of data are widely used for communication and understanding, particularly in science, technology, engineering, and mathematics (STEM). However, despite their importance, many people have difficulty understanding data-based visualizations. This work presents a series of three studies that examine how understanding time-based…

Antioxidants are molecules that act against free radicals, and this effect can bring many benefits to health and society. Antioxidants can be found in various matrices of nature, such as fruits and plants. Some studies have shown that "Rhizophora mangle," a typical mangrove plant, is rich in antioxidants. People report its use for…

There is an increasing need for fundamental electrochemistry concepts to be taught in the undergraduate curriculum, given the broad applicability of electrochemical technologies in addressing a wide range of global issues from critical energy shortages to real-time medical diagnostics. However, many electrochemical concepts are often taught in…