In this paper, we present a concise and technique-heavy route to the synthesis of dimedone for a second-year organic chemistry curriculum. Our preparation of dimedone guides students through a Michael addition followed by a Dieckmann cyclization, basic ester hydrolysis, and thermal decarboxylation, while allowing time for mechanistic discussion…

An understanding of basic organic chemical reactivity is key for many biosciences students. The reactivities of different carbonyl groups affect their function in many biomolecules. A practical class, the two-step synthesis of paracetamol, has been devised to illustrate the electrophilic reactivities of carbonyls, which was covered in the…

The field of DNA nanotechnology has grown rapidly in the past decade and has expanded to multiple laboratories. While lectures in DNA nanotechnology have been introduced in some institutions, laboratory components at the undergraduate level are still lacking. Undergraduate students predominantly learn about DNA nanotechnology through their…

The Arduino microcontroller is finding its way into labs throughout undergraduate physics curricula, from introductory courses to a variety of beyond-the-first-year laboratory classes. At Davidson College, they use Arduinos in a gateway STEM course for students who are interested in energy and the environment. This article describes how students…

Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

Astronomy is one of the few sciences where the data (star-light) can be seen by all. Yet, there is a disconnect between a typical undergraduate lecture and, for example, where a planet may be in the sky and how to observe it. With the advent of moderate cost, high-quality 'back-garden' astronomy, and standard computers powerful enough to produce…

Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…

Course-based undergraduate research experiences (CUREs)have been shown to result in increased science, technology, engineering, and mathematics (STEM) persistence, but such experiences are rarely available for first-year STEM students. This work outlines the development and integration of a CURE into a year-long honors general chemistry laboratory…

Undergraduate physics laboratory exercises are very important in shaping students' attitude to science, especially for future teachers. Recently, it is necessary to look for ways to easily create large quantities of experimental sets, not only for institutional use, but also for sets that can be produced in large quantities and distributed for use…

We describe a project implemented in the honors section of an upper-level analytical chemistry undergraduate course, in which students designed an experiment to compare the performance of two analytical techniques to determine the amount of ascorbic acid in a commercial sample. This project designed for 18 students is composed of three stages. In…

Lipidomics is a discipline that focuses on the identification and quantification of lipids. Although a part of the larger omics field, lipidomics requires specific approaches for the analysis and biological interpretation of datasets. This article presents a series of activities for introducing undergraduate microbiology students to lipidomic…

We developed a curriculum for an upper-level molecular biology course-based undergraduate research laboratory class funded by a National Science Foundation CAREER grant that focuses on identifying new small proteins in the bacterium, "Escherichia coli." Our CURE class has been continually offered each semester for the last 10 years, with…

Undergraduate chemistry laboratory instruction can be considered from many perspectives and addresses multiple educational aims. We critically assess an inventory of "Cognitive Tasks of Experimental Research" for its applicability to chemistry laboratory teaching, and then apply it to an integrated upper-level laboratory course as an…

A modified apparatus for measuring surface tension with the bubble-pressure method is proposed. Compared with a traditional instrument, this apparatus improved the accuracy of maximum pressure difference measurement and achieved the hydrostatic pressure correction. The apparatus was employed to determine the surface tension values of distilled…

A student experiment that uses QuEChERS (quick, easy, cheap, effective, rugged, and safe) methodology for extraction and HPLC for quantitative determination of tocopherols from seeds and nuts is described here. Chromatographic separation is achieved by using a pentafluorophenyl stationary phase which gives enhanced separation of the tocopherols…