The objective of the study was to investigate the effect of computer simulation integrated with jigsaw learning strategy (CSIJLS) on students' attitudes towards chemistry. Additionally, it sought to determine whether the usage of CSIJLS resulted in any changes in attitudes between male and female students. Researchers employed a quantitative research method and a quasi-experimental design. The participants consisted of three classes, with a total of 144 students aged above 18, assigned to two experimental groups and one comparison group. The researchers collected data using a chemistry attitude Likert scale test administered before and after the intervention. One-way ANOVA and independent t-tests were employed to analyse the data. The results of the one-way ANOVA indicated that there was a significant difference in attitude between the three groups after the implementation of CSIJLS among the three groups (t(141) = 93.9, p = 0.000 < 0.05), indicating that students taught through CSIJLS performed significantly better than those taught using the jigsaw learning strategy alone and conventional methods in terms of their chemistry attitude post-test results. Additionally, the independent t-test analyses revealed no significant differences in attitudes towards chemistry between male and female students when they learned through CSIJLS.