Transcription is the critical first step in expressing a gene, during which an RNA polymerase (RNAP) synthesizes an RNA copy of one strand of the DNA that encodes a gene. Here we describe a laboratory experiment that uses a single assay to probe two important steps in transcription: (1) RNAP binding to DNA, and (2) the transcriptional activity of…

The pharmaceutical and medicine manufacturing industry has become the largest industrial sector for the employment of chemists, indicating a need for experiments with a pharmaceutical sciences context in the undergraduate chemistry curriculum. In the pharmaceutical industry, testing drug dissolution is a key analytical task for solid oral dosage…

To best prepare students for the real-world research environment, key skills, including experimental design, data analysis, communication of results, and critical thinking, should be key components of undergraduate science courses. Furthermore, the impact of the COVID-19 pandemic on in-person teaching has resulted in a need to develop courses that…

We present a course-embedded undergraduate research module that involves real-time polymerase chain reaction testing for the presence of SARS-CoV-2 in environmental samples. A positive control RNA was constructed and two RNA extraction methods were compared and a range of primers were available to compare. Using a combination of published…

Given the emphasis placed on laboratory reform and student engagement in authentic science practice, this manuscript outlines the development of a hybrid project-based laboratory (HPBL) curriculum centered around specific instructor goals and provides examples on how those goals were met by the experiments and how the change in curriculum affected…

A national survey on chemistry instructional laboratories was administered to faculty members at four-year postsecondary institutions in the United States for the purpose of exploring levels of inquiry-based instruction implemented in laboratory courses. Respondents were asked to rate the level of choice their students had in deciding six key…

CRISPR-Cas9 is revolutionizing how we conduct scientific research, treat disease, and develop new crops. The widespread impact of this genome-editing technology makes it critical for undergraduate students to understand and engage with this new tool. In this article, we describe a multi-week lab module that teaches undergraduates how to design…

The prompt transfer of cutting-edge science into students' curricula is a challenging task. Often research experiments are too complex or expensive to be translated into a secondary or tertiary education setting. Herein, we introduce a laboratory experiment that translates the recently developed research technique of a wavelength dependent,…

DNA structure has been leveraged in a variety of facets that allow scientists to perform a range of assays, including ones for identification of species, establishing evolutionary relationships between taxa, or even identifying individuals. Here, we present a DNA barcoding method as practical, hands-on approach that connects several experimental…

Progress is made in science by constructing many models (possibly of different complexities), testing them against measurements, and determining which of them explain the data the best. It is my observation, however, that in many introductory physics labs we provide students with the materials and methods to verify the "correct" model of…

Governance and regulation of the use of live animals in research and teaching is examined in Australia, Malaysia, Indonesia, the Philippines, Singapore, Thailand, China, Japan and India. A comparison of the systems in different countries will enable the determination of best practice and fit-forpurpose regulation. The most comprehensive government…

This paper describes the design and implementation of a course-based undergraduate research experience (CURE) sequence in chemistry that links a lower-division, organic chemistry course to an upper-division, analytical chemistry course. The focus of student research is on blood preservation using trehalose derivatives in order to mimic the…

How well does the undergraduate organic chemistry laboratory curriculum prepare students for academic research, or for a bench job in industry? Running experiments that are more representative of research chemistry has the potential to better equip students for working in a research laboratory, while at the same time giving them insight into a…

Chemistry laboratory experiments are invaluable to students' acquisition of necessary synthetic, analytical, and instrumental skills during their undergraduate studies. However, the COVID-19 pandemic rendered face-to-face (f2f), in-person teaching laboratory experiences impossible from late 2019-2020 and forced educators to rapidly develop new…

Undergraduate research experiences benefit students' scientific skills, and recent trends in undergraduate research and education include focusing on interdisciplinary projects and on place-based learning. Here we describe a semester-long pilot interdisciplinary undergraduate research program focused on local aquatic ecosystems, discuss perceived…