Interdisciplinary science learning can play a central role in promoting students' 21st century skills. However, students tend to have low perceived self-efficacy towards 21st century skills, thus limiting the application of their actual scientific competence. This study seeks, based on a 1.5-year intervention study, to promote students' perceived self-efficacy towards 21st century skills through science learning compared to a non-experimental group. During the intervention, everyday life-related scenarios were utilized, with students guided to create core idea maps. Data on students' perceived self-efficacy were collected before and after the intervention. Results showed that students' perceived self-efficacy towards 21st century skills changed in a significantly positively way after the intervention.